Genetic manipulation, especially gene editing, has greatly facilitated the study of various mechanisms. Ace Therapeutics also uses genetic manipulation to help research H. pylori infection mechanisms, colonization mechanisms, immune evasion mechanisms, and survival-related mechanisms. We provide two H. pylori-related genetic manipulation services. One is the genetic manipulation of H. pylori and the other one is gene editing of gastric cells and experimental animals. An overview of our services and our advantages in H. pylori-related genetic manipulation are listed below.
Fig. 1 H. pylori-related gene manipulation - Ace Therapeutics.
Service overview
In the service of genetic manipulation of H. pylori, we provide a selective culture service of H. pylori strains to help study the differences between different H. pylori strains. We also provide gene deletion or overexpression of specific H. pylori genes to help study the pathogenicity, virulence, and survivability of H. pylori. Then, in the service of gene editing of gastric cells and experimental animals, we provide the construction of gene-edited gastric cells and experimental animals to help study the interaction between H. pylori and the host.
All in all, both services can contribute to the study of the mechanisms of H. pylori infection, colonization, and immune evasion and provide insights into the treatment and prevention of H. pylori.
Our advantages in H. pylori-related genetic manipulation
Mature genetic manipulation methods
Ace Therapeutics has mature methods to genetically manipulate H. pylori and gastric cells as well as experimental animals. For example, we use the double-crossover recombination method to knockout genes of H. pylori, and we use CRISPR-Cas9 technology and siRNA silencing technology to perform relevant gene knockout and gene silencing for gastric cells (e.g. GES-1, AGS, SCG-7901).
Professional staff
Ace Therapeutics has professional mechanistic researchers to assist in the study of the mechanism of action between H. pylori and the host. What's more, we have trained H. pylori culture staff to culture and select H. pylori and we also have specialized cell culture staff to culture various gastric cells. Most importantly, we have experienced molecular manipulators to perform gene editing operations.
One-on-one service
Ace Therapeutics provides one-on-one service to fully satisfy your genetic manipulation needs. We make suggestions for genetic manipulation of H. pylori, gastric cells, and experimental animals based on the needs of mechanistic studies. We also give the time of genetically manipulated construction to allow the client to evaluate whether the time is compatible with the research schedule. Ultimately, we provide on-time delivery of genetically manipulated H. pylori, gastric cells, and experimental animals.
Cooperate with us
A thorough solution to the problem of stomach diseases caused by H. pylori requires an in-depth study of the mechanism of interaction between H. pylori and gastric cells. If you encounter problems with mechanistic studies while exploring new targets for the treatment of H. pylori infection or exploring new ideas for the prevention of H. pylori infection, cooperate with us without hesitation. Ace Therapeutics always provides high-level services for H. pylori research. Our experts in mechanistic studies of H. pylori, professional genetic manipulators, cell culture staff, and H. pylori culture staff are always ready to serve you and will patiently address your questions and provide you with appropriate research materials, including genetically manipulated H. pylori, gene-edited gastric cells, and gene-edited experimental animals.
References
- Ji, X.; et al. Construction of novel plasmid vectors for gene knockout in Helicobacter pylori. Current Microbiology. 2016, 73(6): 897-903.
- Singh, V.; et al. Exploring the potential of genome editing CRISPR-Cas9 technology. Gene. 2017, 599: 1-18.
※ All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
